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Genetically determined P2X7 receptor pore...
Journal article

Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity

Abstract

Individual variation in pain sensation makes pain clinical trials quite challenging to interpret. Now, Michael Salter and colleagues report that genetic variation in the P2RX7 gene affects pore formation of the protein and pain sensation in humans.

Authors

Sorge RE; Trang T; Dorfman R; Smith SB; Beggs S; Ritchie J; Austin J-S; Zaykin DV; Meulen HV; Costigan M

Journal

Nature Medicine, Vol. 18, No. 4, pp. 595–599

Publisher

Springer Nature

Publication Date

April 1, 2012

DOI

10.1038/nm.2710

ISSN

1078-8956

Associated Experts

Ruslan Dorfman

Assistant Clinical Professor (Adjunct), Faculty of Health Sciences
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Labels

Fields of Research (FoR)

32 Biomedical and clinical sciences3209 Neurosciences3202 Clinical Sciences42 Health sciences

Medical Subject Headings (MeSH)

Adenosine TriphosphateAnimalsBenzoxazolesCalciumCarbenoxoloneCells, CulturedChronic PainCohort StudiesConnexinsDisease Models, AnimalEnzyme InhibitorsFemaleGenetic LinkageGenome-Wide Association StudyGenotypeHistidineHumansHyperalgesiaMacrophagesMaleMastectomyMiceMice, Inbred StrainsMutationNerve Tissue ProteinsOsteoarthritisPain MeasurementPain ThresholdPeptidesPolymorphism, Single NucleotideQuinolinium CompoundsReceptors, Purinergic P2X7Retrospective StudiesSpecies SpecificityTime FactorsTransfection
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