Journal article
Programmable insect cell carriers for systemic delivery of integrated cancer biotherapy
Abstract
Due to cancer's genetic complexity, significant advances in the treatment of metastatic disease will require sophisticated, multi-pronged therapeutic approaches. Here we demonstrate the utility of a Drosophila melanogaster cell platform for the production and in vivo delivery of multi-gene biotherapeutic systems. We show that cultured Drosophila S2 cell carriers can stably propagate oncolytic viral therapeutics that are highly cytotoxic for …
Authors
Roy DG; Power AT; Bourgeois-Daigneault MC; Falls T; Ferreira L; Stern A; de Souza CT; McCart JA; Stojdl DF; Lichty BD
Journal
Journal of Controlled Release, Vol. 220, No. Pt A, pp. 210–221
Publisher
Elsevier
Publication Date
December 2015
DOI
10.1016/j.jconrel.2015.10.030
ISSN
0168-3659
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsChlorocebus aethiopsDrosophila melanogasterFemaleGene Expression Regulation, NeoplasticGene Expression Regulation, ViralGenetic TherapyHT29 CellsHeLa CellsHumansImmunocompetenceLung NeoplasmsMCF-7 CellsMice, Inbred BALB COncolytic VirotherapyOncolytic VirusesTime FactorsTransfectionTumor BurdenVero CellsXenograft Model Antitumor Assays