Journal article
Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding
Abstract
OBJECTIVES: To evaluate the clinical effectiveness and cost-effectiveness of proton pump inhibitors (PPIs) in the prevention and treatment of acute upper gastrointestinal (UGI) haemorrhage, as well as to compare this with H2-receptor antagonist (H2RA), Helicobacter pylori eradication (in infected patients) or no therapy, for the prevention of first and/or subsequent bleeds among patients who continue to use non-steroidal anti-inflammatory drugs …
Authors
Leontiadis GI; Sreedharan A; Dorward S; Barton P; Delaney B; Howden CW; Orhewere M; Gisbert J; Sharma VK; Rostom A
Journal
Health Technology Assessment, Vol. 11, No. 51, pp. iii–164
Publisher
National Institute for Health and Care Research
Publication Date
December 2007
DOI
10.3310/hta11510
ISSN
1366-5278
Associated Experts
Fields of Research (FoR)
Sustainable Development Goals (SDG)
Medical Subject Headings (MeSH)
Acute DiseaseAgedAnti-Inflammatory Agents, Non-SteroidalCongresses as TopicCost-Benefit AnalysisDatabases, BibliographicDuodenal UlcerEndoscopy, GastrointestinalGastrointestinal HemorrhageHelicobacter InfectionsHelicobacter pyloriHistamine H2 AntagonistsHumansMiddle AgedPeptic Ulcer HemorrhageProton Pump InhibitorsQuality-Adjusted Life YearsRandomized Controlled Trials as TopicTreatment OutcomeUpper Gastrointestinal Tract