Journal article
A Population‐Based Assessment of the Drug Interaction Between Levothyroxine and Warfarin
Abstract
Most drug interaction resources suggest that levothyroxine can dramatically potentiate the effect of warfarin. However, the mechanistic basis of the interaction is speculative, and little evidence supports a meaningful drug interaction. We conducted a population-based nested case-control study to examine the risk of hospitalization for hemorrhage following the initiation of levothyroxine in a cohort of 260,076 older patients receiving warfarin. …
Authors
Pincus D; Gomes T; Hellings C; Zheng H; Paterson JM; Mamdani MM; Juurlink DN
Journal
Clinical Pharmacology & Therapeutics, Vol. 92, No. 6, pp. 766–770
Publisher
Wiley
Publication Date
December 2012
DOI
10.1038/clpt.2012.171
ISSN
0009-9236