Journal article
Pathophysiology and management of chronic immune thrombocytopenia: focusing on what matters
Abstract
Immune thrombocytopenia (ITP) is a common autoimmune disease characterized by low platelet counts and an increased risk of bleeding. Antibody-mediated platelet destruction has been the prevailing hypothesis to explain ITP pathogenesis, supported by the efficacy of B-cell depletion therapy; however, the recent success of thrombopoietin receptor agonists lends support to the notion that platelet production is also insufficient. Best practice for …
Authors
Toltl LJ; Arnold DM
Journal
British Journal of Haematology, Vol. 152, No. 1, pp. 52–60
Publisher
Wiley
Publication Date
January 2011
DOI
10.1111/j.1365-2141.2010.08412.x
ISSN
0007-1048