Journal article
Detection of rupture-prone atherosclerotic plaques by time-resolved laser-induced fluorescence spectroscopy
Abstract
OBJECTIVE: Plaque with dense inflammatory cells, including macrophages, thin fibrous cap and superficial necrotic/lipid core is thought to be prone-to-rupture. We report a time-resolved laser-induced fluorescence spectroscopy (TR-LIFS) technique for detection of such markers of plaque vulnerability in human plaques.
METHODS: The autofluorescence of carotid plaques (65 endarterectomy patients) induced by a pulsed laser (337 nm, 0.7 ns) was …
Authors
Marcu L; Jo JA; Fang Q; Papaioannou T; Reil T; Qiao J-H; Baker JD; Freischlag JA; Fishbein MC
Journal
Atherosclerosis, Vol. 204, No. 1, pp. 156–164
Publisher
Elsevier
Publication Date
May 2009
DOI
10.1016/j.atherosclerosis.2008.08.035
ISSN
0021-9150
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
CalcinosisCarotid Artery DiseasesCarotid Artery, CommonCollagenElastinEndarterectomy, CarotidFeasibility StudiesFiber Optic TechnologyFibrosisFoam CellsHumansLasersLipidsNecrosisPredictive Value of TestsReproducibility of ResultsRuptureSensitivity and SpecificitySpectrometry, FluorescenceTime Factors