Journal article
Interrelationship Between Cardiac Hypertrophy, Heart Failure, and Chronic Kidney Disease
Abstract
Synthesis of transmembrane and secretory proteins occurs within the endoplasmic reticulum (ER) and is extremely important in the normal functioning of both the heart and kidney. The dysregulation of protein synthesis/processing within the ER causes the accumulation of unfolded proteins, thereby leading to ER stress and the activation of the unfolded protein response. Sarcoplasmic reticulum/ER Ca2+ disequilibrium can lead to cardiac hypertrophy …
Authors
Dickhout JG; Carlisle RE; Austin RC
Journal
Circulation Research, Vol. 108, No. 5, pp. 629–642
Publisher
Wolters Kluwer
Publication Date
March 4, 2011
DOI
10.1161/circresaha.110.226803
ISSN
0009-7330