Journal article
Endoplasmic reticulum stress inhibition attenuates hypertensive chronic kidney disease through reduction in proteinuria
Abstract
Endoplasmic reticulum (ER) stress is implicated in chronic kidney disease (CKD) development in patients and in animal models. Here we show that ER stress inhibition through 4-phenylbutyric acid (4-PBA) administration decreases blood pressure, albuminuria, and tubular casts in an angiotensin II/deoxycorticosterone acetate/salt murine model of CKD. Lower albuminuria in 4-PBA-treated mice was associated with higher levels of cubilin protein in …
Authors
Mohammed-Ali Z; Lu C; Marway MK; Carlisle RE; Ask K; Lukic D; Krepinsky JC; Dickhout JG
Journal
Scientific Reports, Vol. 7, No. 1,
Publisher
Springer Nature
DOI
10.1038/srep41572
ISSN
2045-2322
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Angiotensin IIAnimalsApoptosisBiopsyBlood PressureDisease Models, AnimalEndoplasmic Reticulum StressFibrosisGene Expression ProfilingHumansHypertensionInflammationMaleMiceMice, KnockoutNephrosclerosisPhenylbutyratesProteinuriaRenal Insufficiency, ChronicTranscription Factor CHOPTranscriptomeUrinalysis