Journal article
miR-30a inhibits endothelin A receptor and chemoresistance in ovarian carcinoma
Abstract
Drug resistance remains the major clinical barrier to successful treatment in epithelial ovarian carcinoma (EOC) patients, and the evidence of microRNA involvement in drug resistance has been recently emerging. Endothelin-1 (ET-1)/ETA receptor (ETAR) axis is aberrantly activated in chemoresistant EOC cells and elicits pleiotropic effects promoting epithelial-to-mesenchymal transition (EMT) and the acquisition of chemoresistance. However, the …
Authors
Sestito R; Cianfrocca R; Rosanò L; Tocci P; Semprucci E; Di Castro V; Caprara V; Ferrandina G; Sacconi A; Blandino G
Journal
Oncotarget, Vol. 7, No. 4, pp. 4009–4023
Publisher
Impact Journals
Publication Date
January 26, 2016
DOI
10.18632/oncotarget.6546
ISSN
1949-2553
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsApoptosisBlotting, WesternCell MovementCell ProliferationDrug Resistance, NeoplasmEnzyme-Linked Immunosorbent AssayFemaleHumansImmunoenzyme TechniquesMiceMice, NudeMicroRNAsOvarian NeoplasmsRNA, MessengerReal-Time Polymerase Chain ReactionReceptor, Endothelin AReverse Transcriptase Polymerase Chain ReactionTumor Cells, CulturedXenograft Model Antitumor Assays