Journal article
Phylogenetic and Functional Analysis of the Vertebrate Cytochrome P450 2 Family
Abstract
Cytochrome P450 (CYP) proteins compose a highly diverse superfamily found in all domains of life. These proteins are enzymes involved in metabolism of endogenous and exogenous compounds. In vertebrates, the CYP2 family is one of the largest, most diverse and plays an important role in mammalian drug metabolism. However, there are more than 20 vertebrate CYP2 subfamilies with uncertain evolution and fairly discrete subfamily composition within …
Authors
Kirischian N; McArthur AG; Jesuthasan C; Krattenmacher B; Wilson JY
Journal
Journal of Molecular Evolution, Vol. 72, No. 1, pp. 56–71
Publisher
Springer Nature
Publication Date
1 2011
DOI
10.1007/s00239-010-9402-7
ISSN
0022-2844