Journal article
Inhibition of endogenous MTF-1 signaling in zebrafish embryos identifies novel roles for MTF-1 in development
Abstract
The metal responsive element-binding transcription factor-1 (MTF-1) responds to changes in cellular zinc levels caused by zinc exposure or disruption of endogenous zinc homeostasis by heavy metals or oxygen-related stress. Here we report the functional characterization of a complete zebrafish MTF-1 in comparison with the previously identified isoform lacking the highly conserved cysteine-rich motif (Cys-X-Cys-Cys-X-Cys) found in all other …
Authors
O'Shields B; McArthur AG; Holowiecki A; Kamper M; Tapley J; Jenny MJ
Journal
Biochimica et Biophysica Acta, Vol. 1843, No. 9, pp. 1818–1833
Publisher
Elsevier
Publication Date
9 2014
DOI
10.1016/j.bbamcr.2014.04.015
ISSN
0006-3002
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Amino Acid SequenceAnimalsCadmiumCloning, MolecularDNA-Binding ProteinsEmbryo, NonmammalianEmbryonic DevelopmentFemaleGene Expression ProfilingGene Expression Regulation, DevelopmentalGene OntologyHemopexinHumansMaleMiceModels, BiologicalMolecular Sequence DataMutationOligonucleotide Array Sequence AnalysisRNA, MessengerReproducibility of ResultsSignal TransductionTranscription FactorsTranscriptional ActivationZebrafishTranscription Factor MTF-1