Age-related differences in the response of leg muscle cross-sectional area and water diffusivity measures to a period of supine rest

Object The object was to assess whether cross-sectional area (CSA) and water diffusion properties of leg muscles in young and older women change with increased time spent in supine rest.Materials and methodsHealthy young (n = 9, aged 20–30 years) and older (n = 9, aged 65–75 years) women underwent MRI scanning of the right leg at baseline, 30 and 60 min of supine rest. Muscle CSA was derived from proton density images. Water diffusion …