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IGF-1 colocalizes with muscle satellite cells...

Journal article

IGF-1 colocalizes with muscle satellite cells following acute exercise in humans

Abstract

Insulin-like growth factor-1 (IGF-1) regulates stem cell proliferation and differentiation in vitro. The aim of this study was to quantify the change in satellite cell (SC) specific IGF-1 colocalization following exercise. We observed a significant increase (p < 0.05) in the percentage of SC with IGF-1 colocalization from baseline to 72 h after a bout of resistance exercise. This strongly supports a role for IGF-1 in human SC function following exercise.

Authors

Grubb A; Joanisse S; Moore DR; Bellamy LM; Mitchell CJ; Phillips SM; Parise G

Journal

Applied Physiology Nutrition and Metabolism, Vol. 39, No. 4, pp. 514–518

Publisher

Canadian Science Publishing

Publication Date

January 1, 2014

DOI

10.1139/apnm-2013-0430

ISSN

1715-5312

Associated Experts

Gianni Parise

Vice-President, Research

Stuart Phillips

Professor, Faculty of Science

Labels

Fields of Research (FoR)

32 Biomedical and Clinical Sciences 42 Health Sciences 4207 Sports science and exercise 3210 Nutrition and dietetics

Medical Subject Headings (MeSH)

Adolescent Adult Exercise Humans Insulin-Like Growth Factor I Male Satellite Cells, Skeletal Muscle Young Adult

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