Journal article
Identification of an ataxia telangiectasia-mutated protein mediated surveillance system to regulate Bcl-2 overexpression
Abstract
Bcl-2 can both promote and attenuate tumorigenesis. Although the former function is relatively well characterized, the mechanism of the latter remains elusive. We report here that enforced Bcl-2 expression in MCF7 cells stabilizes p53, induces phosphorylation of p53 serine 15 (p53pSer15) and inhibits MCF7 cell growth. Consistent with p53 Ser15 being a target of ataxia telangiectasia mutated protein(ATM)/ATR (ATM- and rad3-related) in the DNA …
Authors
Zhang J; Lahti JM; Bruce A; He L; Parihar K; Fan C; Grenet J; Liu L; Kidd VJ; Cormier S
Journal
Oncogene, Vol. 25, No. 41, pp. 5601–5611
Publisher
Springer Nature
Publication Date
September 14, 2006
DOI
10.1038/sj.onc.1209565
ISSN
0950-9232
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Ataxia Telangiectasia Mutated ProteinsBase SequenceBlotting, WesternBreast NeoplasmsCell Cycle ProteinsCell DivisionCell Line, TumorDNA PrimersDNA-Binding ProteinsFluorescent Antibody TechniqueGene ExpressionHumansProtein Serine-Threonine KinasesProto-Oncogene Proteins c-bcl-2RNA, Small InterferingTumor Suppressor Protein p53Tumor Suppressor Proteins