Journal article
SIPL1 enhances the proliferation, attachment, and migration of CHO cells by inhibiting PTEN function
Abstract
The PTEN tumour suppressor plays critical roles in inhibiting cell proliferation, adhesion and migration through downregulation of the PI3K-AKT pathway. SIPL1 is a novel PTEN‑negative regulator (PTEN-NR) that contributes to PTEN inactivation during tumorigenesis. However, whether SIPL1 plays a role in inhibiting PTEN function in the process of cell adhesion and migration remains unclear. The aim of this study was to investigate this possibility …
Authors
DE MELO J; WU V; HE L; YAN J; TANG D
Journal
International Journal of Molecular Medicine, Vol. 34, No. 3, pp. 835–841
Publisher
Spandidos Publications
Publication Date
9 2014
DOI
10.3892/ijmm.2014.1840
ISSN
1107-3756