Journal article
Effects of a cysteinyl leukotriene receptor antagonist on eosinophil recruitment in experimental allergic rhinitis
Abstract
The cysteinyl leukotrienes (cysLTs) are potent lipid mediators in allergic disease, acting through a receptor (cysLT1-R) which can be targeted in rhinitis and asthma. We investigated the effects of cysLT1-R antagonism in experimental allergic rhinitis, focusing on bone marrow eosinophil progenitor responses. BALB/c mice were sensitized, then given daily intranasal ovalbumin for 2 weeks, with montelukast sodium (5 mg/kg or 2.5 mg/kg) or placebo …
Authors
Saito H; Morikawa H; Howie K; Crawford L; Baatjes AJ; Denburg E; Cyr MM; Denburg JA
Journal
Immunology, Vol. 113, No. 2, pp. 246–252
Publisher
Wiley
Publication Date
10 2004
DOI
10.1111/j.1365-2567.2004.01944.x
ISSN
0019-2805
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AcetatesAnimalsBasophilsBone MarrowCell DifferentiationCulture TechniquesCyclopropanesEosinophilsGranulocyte-Macrophage Colony-Stimulating FactorHematopoiesisInterleukin-3Interleukin-5Leukocyte CountLeukotriene AntagonistsMembrane ProteinsMiceMice, Inbred BALB CNasal MucosaQuinolinesReceptors, LeukotrieneRhinitis, Allergic, PerennialStem CellsSulfides