Conference
Endurance Exercise, Mitochondrial Rejuvenescence and Aging: On Your Mark, Get Set, GO!
Abstract
The role of mitochondrial abnormalities has been extensively characterized in the etiology of systemic decline with aging. A causal role for mitochondrial DNA (mtDNA) mutagenesis in mammalian ageing is supported by recent studies demonstrating that the polymerase gamma (PolG) mutator mouse, harbouring a proofreading‐deficient copy of PolG, exhibits an accelerated aging phenotype, systemic mitochondrial dysfunction, multisystem failure, and …
Authors
Safdar A; Bourgeois JM; Mocellin N; Hettinga BP; Kujoth GC; Prolla TA; Tarnopolsky MA
Volume
24
Pagination
pp. 806.15-806.15
Publisher
Wiley
Publication Date
April 2010
DOI
10.1096/fasebj.24.1_supplement.806.15
Conference proceedings
The FASEB Journal
Issue
S1
ISSN
0892-6638