Journal article
PTEN inhibits BMI1 function independently of its phosphatase activity
Abstract
BackgroundPTEN is the second most mutated tumor suppressor gene other than p53. It suppresses tumorigenesis by dephosphorylating phosphatidylinositol (3,4,5)-triphosphate (PIP3) to phosphatidylinositol (4,5)-biphosphate (PIP2), thereby directly inhibiting phosphatidylinositol 3 kinase (PI3K)-mediated tumorigenic activities. Consistent with this model of action, cytosolic PTEN is recruited to the plasma membrane to dephosphorylate PIP3. While …
Authors
Fan C; He L; Kapoor A; Rybak AP; De Melo J; Cutz J-C; Tang D
Journal
Molecular Cancer, Vol. 8, No. 1,
Publisher
Springer Nature
Publication Date
December 2009
DOI
10.1186/1476-4598-8-98
ISSN
1476-4598
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Amino AcidsCell Line, TumorCell NucleusEnzyme ActivationHumansMaleNuclear ProteinsPTEN PhosphohydrolasePhosphatidylinositol 3-KinasesPolycomb Repressive Complex 1Promoter Regions, GeneticProstatic NeoplasmsProtein BindingProto-Oncogene ProteinsProto-Oncogene Proteins c-aktRepressor ProteinsTelomerase