Journal article
Bone Formation Following Intramedullary Femoral Reaming Is Decreased by Indomethacin and Antibodies to Insulin-like Growth Factors
Abstract
OBJECTIVE: We aimed to: 1). compare rates of in vitro bone formation following reamed and nonreamed intramedullary fixation in a murine model of femoral fracture healing; and 2). examine whether antibodies to insulin-like growth factor (IGF) I, IGF II, or indomethacin (an inhibitor of the inflammatory process) affect bone formation following intramedullary reaming.
DESIGN: Experimental study.
Authors
Bhandari M; Schemitsch EH
Journal
Journal of Orthopaedic Trauma, Vol. 16, No. 10, pp. 717–722
Publisher
Wolters Kluwer
Publication Date
11 2002
DOI
10.1097/00005131-200211000-00006
ISSN
0890-5339