Journal article
Mutational analysis of the herpes simplex virus trans-inducing factor Vmw65
Abstract
Vmw65 is a structural component of herpes simplex virus which, in conjunction with host factors, trans-activates the expression of the viral immediate-early genes. In order to examine the relationship between the primary structure of Vmw65 and its trans-activating function, we generated in-frame insertion, deletion, and nonsense mutations in a cloned copy of the gene. The ability of the mutant polypeptides to function as transcriptional …
Authors
Werstuck G; Capone JP
Journal
Gene, Vol. 75, No. 2, pp. 213–224
Publisher
Elsevier
Publication Date
February 1989
DOI
10.1016/0378-1119(89)90267-9
ISSN
0378-1119