Journal article
Immune-mediated neural dysfunction in a murine model of chronic Helicobacter pylori infection
Abstract
BACKGROUND & AIMS: Neuromuscular changes producing dysmotility and hyperalgesia may underlie symptom generation in functional gastrointestinal disorders. We investigated whether chronic Helicobacter pylori-induced gastritis causes neuromuscular dysfunction.
METHODS: In vitro muscle contractility and acetylcholine release were evaluated in mice before and after H. pylori eradication. H. pylori colonization and gastritis were graded …
Authors
Berčík P; De Giorgio R; Blennerhassett P; Verdú EF; Barbara G; Collins SM
Journal
Gastroenterology, Vol. 123, No. 4, pp. 1205–1215
Publisher
Elsevier
Publication Date
October 2002
DOI
10.1053/gast.2002.36024
ISSN
0016-5085
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AcetylcholineAnimalsCalcitonin Gene-Related PeptideDisease Models, AnimalEnteric Nervous SystemFemaleGastritisHelicobacter InfectionsHelicobacter pyloriImmunohistochemistryMacrophagesMiceMice, Inbred BALB CMice, SCIDMuscle ContractionSpecific Pathogen-Free OrganismsSpinal CordStomachSubstance PVasoactive Intestinal Peptide