Journal article
Chronic Gastrointestinal Inflammation Induces Anxiety-Like Behavior and Alters Central Nervous System Biochemistry in Mice
Abstract
BACKGROUND & AIMS: Clinical and preclinical studies have associated gastrointestinal inflammation and infection with altered behavior. We investigated whether chronic gut inflammation alters behavior and brain biochemistry and examined underlying mechanisms.
METHODS: AKR mice were infected with the noninvasive parasite Trichuris muris and given etanercept, budesonide, or specific probiotics. Subdiaphragmatic vagotomy was performed in a subgroup …
Authors
Bercik P; Verdu EF; Foster JA; Macri J; Potter M; Huang X; Malinowski P; Jackson W; Blennerhassett P; Neufeld KA
Journal
Gastroenterology, Vol. 139, No. 6, pp. 2102–2112.e1
Publisher
Elsevier
Publication Date
December 2010
DOI
10.1053/j.gastro.2010.06.063
ISSN
0016-5085