Journal article
Familial dysmyelination in a Long Evans rat mutant.
Abstract
Tremors were observed in 15 Long Evans rats beginning at 10 to 12 days of age. These were followed by progressively worsening ataxia, hind limb paresis, episodes of immobility, and seizures by 5 to 14 weeks. Gross lesions were not observed at necropsy in rats euthanized and perfused at 4 to 16 weeks of age. Neurohistologic examination revealed dysmyelination in the central nervous system. Astrogliosis in the white matter with marked increase of …
Authors
Delaney KH; Kwiecien JM; Wegiel J; Wisniewski HM; Percy DH; Fletch AL
Journal
Journal of the American Association for Laboratory Animal Science, Vol. 45, No. 5, pp. 547–553
Publication Date
October 1995
ISSN
1559-6109