Journal article
Phase II Study of Temsirolimus in Women With Recurrent or Metastatic Endometrial Cancer: A Trial of the NCIC Clinical Trials Group
Abstract
PURPOSE: Phosphatase and tensin homolog (PTEN) is a tumor suppressor gene, and loss of function mutations are common and appear to be important in the pathogenesis of endometrial carcinomas. Loss of PTEN causes deregulated phosphatidylinositol-3 kinase/serine-threonine kinase/mammalian target of rapamycin (PI3K/Akt/mTOR) signaling which may provide neoplastic cells with a selective survival advantage by enhancing angiogenesis, protein …
Authors
Oza AM; Elit L; Tsao M-S; Kamel-Reid S; Biagi J; Provencher DM; Gotlieb WH; Hoskins PJ; Ghatage P; Tonkin KS
Journal
Journal of Clinical Oncology, Vol. 29, No. 24, pp. 3278–3285
Publisher
American Society of Clinical Oncology (ASCO)
Publication Date
August 20, 2011
DOI
10.1200/jco.2010.34.1578
ISSN
0732-183X