Journal article
Immunochip Analysis Identifies Multiple Susceptibility Loci for Systemic Sclerosis
Abstract
In this study, 1,833 systemic sclerosis (SSc) cases and 3,466 controls were genotyped with the Immunochip array. Classical alleles, amino acid residues, and SNPs across the human leukocyte antigen (HLA) region were imputed and tested. These analyses resulted in a model composed of six polymorphic amino acid positions and seven SNPs that explained the observed significant associations in the region. In addition, a replication step comprising …
Authors
Mayes MD; Bossini-Castillo L; Gorlova O; Martin JE; Zhou X; Chen WV; Assassi S; Ying J; Tan FK; Arnett FC
Journal
American Journal of Human Genetics, Vol. 94, No. 1, pp. 47–61
Publisher
Elsevier
Publication Date
January 2014
DOI
10.1016/j.ajhg.2013.12.002
ISSN
0002-9297
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AllelesAutophagy-Related Protein 5Carrier ProteinsCase-Control StudiesChromosomes, Human, Pair 11Chromosomes, Human, Pair 3DEAD-box RNA HelicasesEndodeoxyribonucleasesFemaleGenetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHLA AntigensHumansInterleukin-12 Subunit p35Linkage DisequilibriumLogistic ModelsMaleMicrochip Analytical ProceduresMicrotubule-Associated ProteinsPolymorphism, Single NucleotideProto-Oncogene ProteinsRisk FactorsScleroderma, SystemicWhite People