Journal article
Long-Term Effects of Indomethacin Prophylaxis in Extremely-Low-Birth-Weight Infants
Abstract
BACKGROUND: The prophylactic administration of indomethacin reduces the frequency of patent ductus arteriosus and severe intraventricular hemorrhage in very-low-birth-weight infants (those with birth weights below 1500 g). Whether prophylaxis with indomethacin confers any long-term benefits that outweigh the risks of drug-induced reductions in renal, intestinal, and cerebral blood flow is not known.
METHODS: Soon after they were born, we …
Authors
Schmidt B; Davis P; Moddemann D; Ohlsson A; Roberts RS; Saigal S; Solimano A; Vincer M; Wright LL
Journal
The New England Journal of Medicine, Vol. 344, No. 26, pp. 1966–1972
Publisher
Massachusetts Medical Society
Publication Date
June 28, 2001
DOI
10.1056/nejm200106283442602
ISSN
0028-4793