Heartburn‐dominant, uninvestigated dyspepsia: a comparison of ‘PPI‐start’ and ‘H2‐RA‐start’ management strategies in primary care – the CADET‐HR Study

BACKGROUND: There are few data on empiric, stepped therapy for heartburn relief or subsequent relapse in primary care. AIMS: To compare heartburn relief produced by a proton pump inhibitor-start or an H(2)-receptor antagonist-start with step-up therapy, as needed, followed by a treatment-free period to assess relapse.