Journal article
Ligands of diltiazem binding site: an overview of some chemotypes.
Abstract
The diltiazem binding site of L-type calcium channels is the least characterized to date. In this paper, we present some of the available chemotypes that bind to the benzothiazepine binding site: natural compounds, compounds synthesized by varying the benzothiazepine scaffold, and compounds discovered by means of computational approaches.
Authors
Budriesi R; Ioan P; Carosati E; Cruciani G; Zhorov BS; Chiarini A
Journal
Mini-Reviews in Medicinal Chemistry, Vol. 9, No. 12, pp. 1379–1388
Publisher
Bentham Science Publishers
Publication Date
October 2009
DOI
10.2174/138955709789957369
ISSN
1389-5575