Journal article
Continuous antigenic stimulation system (CASS) as a new immunization strategy
Abstract
Protection against diseases is mediated by a sustained immune response. Here, we describe a new immunization strategy. Mice implanted with encapsulated C2C12 myoblasts secreting human factor IX (hFIX) elicited a strong humoral response against the transgene, as compared to mice immunized with complete Freund's adjuvant (FA). Mice also had increasing IgG2a antibody titer, indicating a switch to a Th1 profile immune response. Mice developed …
Authors
Gomez-Vargas A; Rosenthal KL; McDermott MR; Hortelano G
Journal
Vaccine, Vol. 22, No. 29-30, pp. 3902–3910
Publisher
Elsevier
Publication Date
September 2004
DOI
10.1016/j.vaccine.2004.04.010
ISSN
0264-410X