Journal article
Nongenotoxic carcinogens shift cultured rat hepatocytes into G1 cell cycle phase: influence of tissue oxygen tension on cells with different ploidy.
Abstract
The transition of quiescent freshly isolated rat hepatocytes (G0 phase) into a prereplicative stage of the cell cycle (G1 phase) has been visualized by a decrease in fluorescence of quinacrine dihydrochloride (QDH)-stained nuclei. This transition might be used as an early detectable and sensitive marker for the identification of chemicals with a mitogenic potential. This was tested with three presumedly nongenotoxic carcinogens in the rodent, …
Authors
Duivenvoorden WC; Maier P
Journal
European Journal of Cell Biology, Vol. 64, No. 2, pp. 368–375
Publication Date
August 1994
ISSN
0171-9335