Journal article
Use of a Fixed Activated Partial Thromboplastin Time Ratio to Establish a Therapeutic Range for Unfractionated Heparin
Abstract
BACKGROUND: The commonly recommended therapeutic range for patients receiving unfractionated heparin of 1.5 to 2.5 times the control activated partial thromboplastin time (aPTT) is not universally applicable. It has been suggested that the therapeutic range for each aPTT reagent should be based on plasma heparin levels. We sought to identify an aPTT ratio that corresponds to therapeutic anti--factor Xa heparin levels for combinations of several …
Authors
Bates SM; Weitz JI; Johnston M; Hirsh J; Ginsberg JS
Journal
JAMA Internal Medicine, Vol. 161, No. 3, pp. 385–391
Publisher
American Medical Association (AMA)
Publication Date
February 12, 2001
DOI
10.1001/archinte.161.3.385
ISSN
2168-6106