Journal article
Immunization with adenovirus at the large intestinal mucosa as an effective vaccination strategy against sexually transmitted viral infection
Abstract
The large intestinal mucosa contains immunological structures that may potentially serve as a site for induction of mucosal immunity against infections. Adenovirus (Ad), which is effective in gene transfer to epithelia, may be an ideal antigen delivery system for vaccination at the large intestinal mucosa. To investigate this potential, we immunized mice with recombinant replication-deficient Ad through a single intracolorectal (ICR) …
Authors
Zhu Q; Thomson CW; Rosenthal KL; McDermott MR; Collins SM; Gauldie J
Journal
Mucosal Immunology, Vol. 1, No. 1, pp. 78–88
Publisher
Elsevier
Publication Date
January 2008
DOI
10.1038/mi.2007.3
ISSN
1933-0219