Journal article
A mouse GM-CSF receptor antibody attenuates neutrophilia in mice exposed to cigarette smoke
Abstract
We investigated the role of granulocyte-macrophage colony-stimulating factor (GM-CSF) in a subchronic exposure model of cigarette smoke (CS)-induced inflammation using antibodies directed against GM-CSF or the GM-CSF receptor (GM-CSFR) α-chain. CS-induced mononuclear and neutrophilic inflammation following 4 days of CS exposure in BALB/c mice was assessed in bronchoalveolar lavage (BAL) fluid. An increase in mature dendritic cells (DCs) (CD11c+ …
Authors
Botelho FM; Nikota JK; Bauer C; Davis NHE; Cohen ES; Anderson IK; Coyle AJ; Kolbeck R; Humbles AA; Stämpfli MR
Journal
European Respiratory Journal, Vol. 38, No. 2, pp. 285–294
Publisher
European Respiratory Society (ERS)
Publication Date
August 2011
DOI
10.1183/09031936.00076210
ISSN
0903-1936
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsAntibodiesAntigens, CDAntigens, Differentiation, T-LymphocyteBronchoalveolar Lavage FluidCD11c AntigenCD8-Positive T-LymphocytesDendritic CellsFemaleGenes, MHC Class IIGranulocyte-Macrophage Colony-Stimulating FactorInterleukin-12 Subunit p40Lectins, C-TypeLungMiceMice, Inbred BALB CMice, KnockoutNeutrophilsReceptors, ChemokineReceptors, Granulocyte-Macrophage Colony-Stimulating FactorReceptors, Interleukin-1Smoking