Induction of pulmonary antibodies against oxidized lipids in mice exposed to cigarette smoke

BackgroundChronic cigarette smoke exposure is known to activate the adaptive immune system; however, the functional role of these processes is currently unknown. Given the role of oxidized lipids in driving innate inflammatory responses to cigarette smoke, we investigated whether an adaptive immune response against damaged lipids was induced following chronic cigarette smoke exposure.Methods and resultsUsing a well-established mouse model, we …