Journal article
Influence of thrombophilia on risk of recurrent venous thromboembolism while on warfarin: results from a randomized trial
Abstract
We sought to determine whether thrombophilic defects increase recurrent venous thromboembolism (VTE) during warfarin therapy. Six hundred sixty-one patients with unprovoked VTE who were randomized to extended low-intensity (international normalized ratio [INR], 1.5-1.9) or conventional-intensity (INR, 2.0-3.0) anticoagulant therapy were tested for thrombophilia and followed for a mean of 2.3 years. One or more thrombophilic defects were present …
Authors
Kearon C; Julian JA; Kovacs MJ; Anderson DR; Wells P; MacKinnon B; Weitz JI; Crowther MA; Dolan S; Turpie AG
Journal
Blood, Vol. 112, No. 12, pp. 4432–4436
Publisher
American Society of Hematology
Publication Date
December 1, 2008
DOI
10.1182/blood-2008-06-163279
ISSN
0006-4971