Journal article
RhoA/Rho-Kinase Contribute to the Pathogenesis of Diabetic Renal Disease
Abstract
OBJECTIVE: Accumulation of glomerular matrix proteins is central to the pathogenesis of diabetic nephropathy, with resident mesangial cells (MCs) known to upregulate matrix protein synthesis in response to high glucose. Because activation of the GTPase RhoA has been implicated in matrix upregulation, we studied its role in induction of the matrix protein fibronectin in diabetic MCs and in vivo in diabetic nephropathy.
RESEARCH DESIGN AND …
Authors
Peng F; Wu D; Gao B; Ingram AJ; Zhang B; Chorneyko K; McKenzie R; Krepinsky JC
Journal
Diabetes, Vol. 57, No. 6, pp. 1683–1692
Publisher
American Diabetes Association
Publication Date
June 1, 2008
DOI
10.2337/db07-1149
ISSN
0012-1797