Journal article
NKT-cell help to B lymphocytes can occur independently of cognate interaction
Abstract
CD4(+) T (Th)-cell help to B lymphocytes requires cognate interaction and CD40 engagement. Invariant natural killer T (iNKT) cells are innate-like T lymphocytes that recognize alphagalactosylceramide (alphaGalCer) presented by CD1d, and can help B-cell responses. We asked whether alphaGalCer-activated iNKT cells help B lymphocytes through cognate interaction, or indirectly, via enhancement of Th-B-cell interaction. After immunization with …
Authors
Tonti E; Galli G; Malzone C; Abrignani S; Casorati G; Dellabona P
Journal
Blood, Vol. 113, No. 2, pp. 370–376
Publisher
American Society of Hematology
Publication Date
January 8, 2009
DOI
10.1182/blood-2008-06-166249
ISSN
0006-4971
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Adjuvants, ImmunologicAnimalsAntibody FormationAntigen PresentationAntigen-Presenting CellsAntigens, CD1dB-LymphocytesBone Marrow TransplantationCD40 AntigensCell CommunicationGalactosylceramidesHistocompatibility Antigens Class IIImmunity, InnateImmunizationMiceMice, KnockoutNatural Killer T-CellsT-Lymphocytes, Helper-InducerTransplantation Chimera