Journal article
Transient Transgene Expression of Decorin in the Lung Reduces the Fibrotic Response to Bleomycin
Abstract
Pulmonary fibrosis is a chronic progressive disease with no effective therapy. Transforming growth factor beta (TGF-beta) is thought to be a key profibrotic mediator and blocking its activity is therefore one of the targets of new treatment strategies for fibrosis. Decorin is an endogenous proteoglycan and one of the known inhibitors of TGF-beta. The short half-life of peptide-based therapeutics makes gene transfer a promising approach to …
Authors
KOLB M; MARGETTS PJ; GALT T; SIME PJ; XING Z; SCHMIDT M; GAULDIE J
Journal
American Journal of Respiratory and Critical Care Medicine, Vol. 163, No. 3, pp. 770–777
Publisher
American Thoracic Society
Publication Date
March 1, 2001
DOI
10.1164/ajrccm.163.3.2006084
ISSN
1073-449X