Journal article
Immunization With a Bivalent Adenovirus-vectored Tuberculosis Vaccine Provides Markedly Improved Protection Over Its Monovalent Counterpart Against Pulmonary Tuberculosis
Abstract
Recombinant virus-vectored vaccines hold great promise for tuberculosis (TB) vaccination strategies. However, there is a lack of side-by-side comparative investigations to dissect the functional differences and support the advantage of multivalent virus-vectored vaccine over its monovalent counterpart. We previously successfully developed a monovalent adenovirus (Ad)-vectored vaccine expressing Ag85a (AdAg85a) and demonstrated its superior …
Authors
Mu J; Jeyanathan M; Small C-L; Zhang X; Roediger E; Feng X; Chong D; Gauldie J; Xing Z
Journal
Molecular Therapy, Vol. 17, No. 6, pp. 1093–1100
Publisher
Elsevier
Publication Date
June 2009
DOI
10.1038/mt.2009.60
ISSN
1525-0016