Journal article
Eosinophils and T Lymphocytes Possess Distinct Roles in Bleomycin-Induced Lung Injury and Fibrosis
Abstract
Leukocyte infiltration is characteristic of lung injury and fibrosis, and its role during tissue repair and fibrosis is incompletely understood. We found that overexpression of IL-5 in transgenic mice (IL-5(TG)) or by adenoviral gene transfer increased bleomycin (blm)-induced lung injury, fibrosis, and eosinophilia. Surprisingly, blm-treated IL-5-deficient (IL-5(-/-)) mice also developed pronounced pulmonary fibrosis but characterized by marked …
Authors
Huaux F; Liu T; McGarry B; Ullenbruch M; Xing Z; Phan SH
Journal
The Journal of Immunology, Vol. 171, No. 10, pp. 5470–5481
Publisher
Oxford University Press (OUP)
Publication Date
November 15, 2003
DOI
10.4049/jimmunol.171.10.5470
ISSN
0022-1767
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsAntibodies, MonoclonalBleomycinCD3 ComplexCell SeparationCells, CulturedCoculture TechniquesCytokinesDisease Models, AnimalEosinophilsGenetic VectorsInflammationInterleukin-5LungMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicPulmonary EosinophiliaPulmonary FibrosisT-Lymphocyte SubsetsTh2 Cells