Journal article
Immunotherapeutic effects of recombinant adenovirus encoding granulocyte–macrophage colony-stimulating factor in experimental pulmonary tuberculosis
Abstract
BALB/c mice with pulmonary tuberculosis (TB) develop a T helper cell type 1 that temporarily controls bacterial growth. Bacterial proliferation increases, accompanied by decreasing expression of interferon (IFN)-γ, tumour necrosis factor (TNF)-α and inducible nitric oxide synthase (iNOS). Activation of dendritic cells (DCs) is delayed. Intratracheal administration of only one dose of recombinant adenoviruses encoding granulocyte-macrophage …
Authors
Francisco-Cruz A; Mata-Espinosa D; Estrada-Parra S; Xing Z; Hernández-Pando R
Journal
Clinical & Experimental Immunology, Vol. 171, No. 3, pp. 283–297
Publisher
Oxford University Press (OUP)
Publication Date
February 4, 2013
DOI
10.1111/cei.12015
ISSN
0009-9104