Journal article
Single Mucosal, but Not Parenteral, Immunization with Recombinant Adenoviral-Based Vaccine Provides Potent Protection from Pulmonary Tuberculosis
Abstract
Bacillus Calmette-Guerin (BCG) vaccine has failed to control the global tuberculosis (TB) epidemic, and there is a lack of safe and effective mucosal vaccines capable of potent protection against pulmonary TB. A recombinant replication-deficient adenoviral-based vaccine expressing an immunogenic Mycobacterium tuberculosis Ag Ag85A (AdAg85A) was engineered and evaluated for its potential to be used as a respiratory mucosal TB vaccine in a murine …
Authors
Wang J; Thorson L; Stokes RW; Santosuosso M; Huygen K; Zganiacz A; Hitt M; Xing Z
Journal
The Journal of Immunology, Vol. 173, No. 10, pp. 6357–6365
Publisher
Oxford University Press (OUP)
Publication Date
November 15, 2004
DOI
10.4049/jimmunol.173.10.6357
ISSN
0022-1767
Associated Experts
Fields of Research (FoR)
Sustainable Development Goals (SDG)
Medical Subject Headings (MeSH)
AcyltransferasesAdenoviridaeAdministration, IntranasalAnimalsAntigens, BacterialCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesFemaleGenetic VectorsImmunity, CellularImmunization, SecondaryInjections, IntramuscularInjections, SubcutaneousMiceMice, Inbred BALB CMycobacterium bovisMycobacterium tuberculosisRespiratory MucosaTuberculosis VaccinesTuberculosis, PulmonaryVaccines, DNAVaccines, SyntheticViral Vaccines