Journal article
Mucosally Delivered Dendritic Cells Activate T Cells Independently of IL-12 and Endogenous APCs
Abstract
In vitro manipulated dendritic cells (DC) have increasingly been used as a promising vaccine formulation against cancer and infectious disease. However, improved understanding of the immune mechanisms is needed for the development of safe and efficacious mucosal DC immunization. We have developed a murine model of respiratory mucosal immunization by using a genetically manipulated DC vaccine. Within 24 h of intranasal delivery, the majority of …
Authors
McCormick S; Santosuosso M; Small C-L; Shaler CR; Zhang X; Jeyanathan M; Mu J; Takenaka S; Ngai P; Gauldie J
Journal
The Journal of Immunology, Vol. 181, No. 4, pp. 2356–2367
Publisher
Oxford University Press (OUP)
Publication Date
August 15, 2008
DOI
10.4049/jimmunol.181.4.2356
ISSN
0022-1767
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AcyltransferasesAdministration, IntranasalAdoptive TransferAmino Acid SequenceAnimalsAntigen-Presenting CellsAntigens, BacterialBacterial ProteinsDendritic CellsDisease Models, AnimalFemaleGenetic VectorsInterleukin-12Lymphocyte ActivationMiceMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutMolecular Sequence DataNasal MucosaT-Lymphocyte Subsets