Journal article
Mechanisms responsible for the failure of protamine to inactivate low‐molecular‐weight heparin
Abstract
Protamine is unable to completely reverse the anticoagulant effect of the low-molecular-weight heparins (LMWH), a fact of clinical importance given the rapid increase in use of LMWH in clinical practice. This investigation sought to determine the mechanism by which LMWH were able to resist protamine-mediated inactivation. Affinity fractionation of LMWH by passage through a protamine column, with subsequent determination of molecular mass and …
Authors
Crowther MA; Berry LR; Monagle PT; Chan AKC
Journal
British Journal of Haematology, Vol. 116, No. 1, pp. 178–186
Publisher
Wiley
Publication Date
January 2002
DOI
10.1046/j.1365-2141.2002.03233.x
ISSN
0007-1048