Journal article
Dose-finding and pharmacokinetic profiles of prophylactic doses of a low molecular weight heparin (reviparin–sodium) in pediatric patients
Abstract
INTRODUCTION: The low molecular weight heparin (LMWH), reviparin-sodium was studied in dose-finding and pharmacokinetic studies in children with central venous lines (CVLs).
MATERIALS AND METHODS: The dose-finding study was performed in 24 patients aged 3 days to 16 years. Dose adjustments were made using a nomogram based on anti-factor Xa levels (units (U)/ml) (target of 0.1-0.3 U/ml). The pharmacokinetic study was performed in 19 patients, 9 …
Authors
Massicotte P; Julian JA; Marzinotto V; Gent M; Shields K; Chan AK; Szechtman B; Kohne S; Shepherd S; Bacher P
Journal
Thrombosis Research, Vol. 109, No. 2-3, pp. 93–99
Publisher
Elsevier
Publication Date
January 2003
DOI
10.1016/s0049-3848(03)00100-2
ISSN
0049-3848