Journal article
Receptors and signaling pathway underlying relaxations to isoprostanes in canine and porcine airway smooth muscle
Abstract
Using muscle bath techniques, we examined the inhibitory activities of several E- and F-ring isoprostanes in canine and porcine airway smooth muscle. 8-Isoprostaglandin E1 and 8-isoprostaglandin E2 (8-iso PGE2) reversed cholinergic tone in a concentration-dependent manner, whereas the F-ring isoprostanes were ineffective. Desensitization with 8-iso-PGE2 and PGE2 implicated isoprostane activity at the PGE2 receptor (EP). We found that the …
Authors
Catalli A; Zhang D; Janssen LJ
Journal
American Journal of Physiology - Lung Cellular and Molecular Physiology, Vol. 283, No. 5, pp. l1151–l1159
Publisher
American Physiological Society
Publication Date
November 1, 2002
DOI
10.1152/ajplung.00038.2002
ISSN
1040-0605