Journal article
Anticoagulant mechanisms of covalent antithrombin-heparin investigated by thrombelastography
Abstract
We have developed an antithrombin-heparin covalent complex (ATH) which inhibits coagulation enzymes by two mechanisms: directly, or by catalytic activation of plasma antithrombin (AT). Anticoagulation by ATH was compared to unfractionated heparin (UFH) or low-molecular-weight heparin (LMWH) using a blood-based, tissue factor (TF)-activated thrombelastography (TEG) assay. Simplified TEG assays with plasma or purified plasma components were used …
Authors
Atkinson HM; Mewhort-Buist TA; Berry LR; Chan AKC
Journal
Thrombosis and Haemostasis, Vol. 102, No. 01, pp. 62–68
Publisher
Thieme
Publication Date
2009
DOI
10.1160/th08-11-0769
ISSN
0340-6245