Journal article
Influence of airway wall stiffness and parenchymal tethering on the dynamics of bronchoconstriction
Abstract
Understanding how tissue remodeling affects airway responsiveness is of key importance, but experimental data bearing on this issue remain scant. We used lung explants to investigate the effects of enzymatic digestion on the rate and magnitude of airway narrowing induced by acetylcholine. To link the observed changes in narrowing dynamics to the degree of alteration in tissue mechanics, we compared our experimental results with predictions made …
Authors
Khan MA; Ellis R; Inman MD; Bates JHT; Sanderson MJ; Janssen LJ
Journal
American Journal of Physiology - Lung Cellular and Molecular Physiology, Vol. 299, No. 1, pp. l98–l108
Publisher
American Physiological Society
Publication Date
July 2010
DOI
10.1152/ajplung.00011.2010
ISSN
1040-0605