Journal article
Immobilization of an antithrombin–heparin complex on gold: Anticoagulant properties and platelet interactions
Abstract
The anticoagulant properties and platelet interactions of gold surfaces modified with an antithrombin-heparin (ATH) complex are reported. ATH was attached to gold through either a short disulfide (linker) or a thiol-terminated polyethylene oxide (PEO) (linker, spacer). Analogous surfaces were prepared with uncomplexed heparin. Antithrombin (AT) uptake was measured before and after selectively destroying the active pentasaccharide sequence of …
Authors
Sask KN; McClung WG; Berry LR; Chan AKC; Brash JL
Journal
Acta Biomaterialia, Vol. 7, No. 5, pp. 2029–2034
Publisher
Elsevier
Publication Date
May 2011
DOI
10.1016/j.actbio.2011.01.031
ISSN
1742-7061