Journal article
Covalently linking heparin to antithrombin enhances prothrombinase inhibition on activated platelets
Abstract
Factor (F)Xa within the prothrombinase complex is protected from inhibition by unfractionated heparin (UFH), enoxaparin and fondaparinux. We have developed a covalent antithrombin-heparin complex (ATH) with enhanced anticoagulant activity. We have also demonstrated that ATH is superior at inhibiting coagulation factors when assembled on artificial surfaces. The objective of the present study is to determine the ability of ATH vs AT+UFH to …
Authors
Stevic I; Chan HHW; Chander A; Berry LR; Chan AKC
Journal
Thrombosis and Haemostasis, Vol. 109, No. 06, pp. 1016–1024
Publisher
Thieme
Publication Date
2013
DOI
10.1160/th12-10-0766
ISSN
0340-6245